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  • Biophysics and Nanotechnology of Ion Channels
    Biophysics and Nanotechnology of Ion Channels

    This book provides a comprehensive review of the biophysics and nanotechnology of ion channels.It details the biological and physiological entities of ion channels in cells and addresses various physical perspectives of ion channel structures and functions.Naturally inbuilt and artificial applicable nanotechnologies of ion channels are modelled and explored.It discusses various methods that can be utilized toward understanding ion channel-based cellular diseases.Physical, biochemical, biomedical, and bioinformatics techniques are taken into consideration to enable the development of strategies to address therapeutic drug discovery and delivery. This book will be of interest to advanced undergraduate and graduate students in biophysics and related biomedical sciences in addition to researchers in the field and industry. Features: Provides a stimulating introduction to the structures and functions of ion channels of biological cell membranes and discusses the biophysics of ion channels in condensed matter state and physiological condition Addresses natural processes and nanotechnology opportunities for their purposeful manipulation Lays the groundwork for vitally important medical advancesMohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing the principles and techniques of physics.He is an associate professor at King Saud University’s Biochemistry Department of College of Science, Riyadh, Saudi Arabia, the co-founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada.He also authored Nanoscale Biophysics of the Cell and Membrane Biophysics.

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  • The Channels of Acupuncture : The Channels of Acupuncture
    The Channels of Acupuncture : The Channels of Acupuncture

    One of the most highly-regarded and respected authors and lecturers in the West, Giovanni Maciocia, illuminates and examines the art of traditional Chinese acupuncture with this in-depth look at the secondary channels and other key structures encompassing the human body in Chinese anatomy. This book describes in detail the pathways, pathology, diagnosis, and treatment of the Luo, Muscle, and Divergent secondary channels, as well as other key structures such as the Cou Li and Huang membranes, and gives a thorough, clear overview of subjects poorly understood and incompletely covered in other English language texts.Over one third of the book is dedicated to the Eight Extraordinary Channels, providing the reader with the most in-depth information available in the English language.Drawing on his broad clinical experience, the author covers the energetic physiology, pathology and points by body area, providing ease of access for both the student and practitioner of acupuncture. The Channels of Acupuncture presents comprehensive and clear information on an essential part of traditional Chinese medicine. Covers key channels not thoroughly discussed in other texts, giving all students and practitioners detailed and clear material to guide them in their practice of acupuncture. Offers new information and insight on other key body structures in Chinese medicine including extraordinary vessels as well as the Cou Li and Huang membranes. Clear illustrations depict the exact channel pathways, diminishing any confusion about their location. Case histories and research from Giovanni Maciocia present a wide range of experiences and examples of clinical practice and study.

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  • Are the potassium ion channels always open?

    No, potassium ion channels are not always open. These channels can be either open or closed, depending on the conditions and signals in the cell. The opening and closing of potassium ion channels are regulated by various factors, including changes in membrane potential, intracellular signaling molecules, and the presence of specific ligands. This regulation allows the cell to control the flow of potassium ions and maintain proper electrical and chemical balance.

  • Why do the sodium ion channels open first and then the potassium ion channels during the action potential?

    Sodium ion channels open first during the action potential because they have a lower threshold for activation compared to potassium ion channels. This means that they are more sensitive to changes in membrane potential and will open more quickly in response to a depolarization. Once the sodium ion channels open and sodium rushes into the cell, causing depolarization, the potassium ion channels then open to repolarize the cell by allowing potassium to leave the cell. This sequential opening of ion channels allows for the rapid and coordinated changes in membrane potential that underlie the action potential.

  • What are the differences of the sodium ion channels?

    Sodium ion channels are membrane proteins that allow the passage of sodium ions across the cell membrane. There are several types of sodium ion channels, including voltage-gated sodium channels, ligand-gated sodium channels, and leak sodium channels. Voltage-gated sodium channels open in response to changes in membrane potential, allowing sodium ions to flow into the cell. Ligand-gated sodium channels open in response to the binding of specific molecules, such as neurotransmitters, allowing sodium ions to enter the cell. Leak sodium channels, on the other hand, are always open and allow a small, constant flow of sodium ions into the cell. Each type of sodium ion channel has different mechanisms of activation and regulation, and they play distinct roles in the function of excitable cells such as neurons and muscle cells.

  • What is the significance of voltage-gated sodium ion channels?

    Voltage-gated sodium ion channels play a crucial role in the generation and propagation of action potentials in neurons and muscle cells. These channels open in response to changes in membrane potential, allowing sodium ions to flow into the cell and depolarize the membrane. This rapid depolarization is essential for the transmission of electrical signals along the cell membrane. Dysfunction of voltage-gated sodium ion channels can lead to various neurological and muscular disorders.

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    Count UP/Down Channels Clock Mute Kitchen Timer Smart 3 Channels Timer Alarm Clock 3 Channels

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  • What happens during the action potential when the Na+ ion channels are blocked?

    When the Na+ ion channels are blocked, the influx of sodium ions into the cell is prevented. This results in the cell membrane being unable to depolarize properly, leading to a decrease in the amplitude of the action potential. As a result, the transmission of the electrical signal along the neuron is disrupted, affecting communication between neurons. This can lead to impaired nerve function and communication within the nervous system.

  • Why are some voltage-gated sodium ion channels opened starting from the resting potential?

    Voltage-gated sodium ion channels are opened starting from the resting potential because they are sensitive to changes in membrane potential. When the membrane potential becomes more positive, it triggers a conformational change in the channel protein, leading to its opening. This allows sodium ions to flow into the cell, depolarizing the membrane and initiating an action potential. This process is essential for the transmission of electrical signals in neurons and muscle cells.

  • Why are some voltage-gated sodium ion channels opened starting from the resting membrane potential?

    Voltage-gated sodium ion channels are opened starting from the resting membrane potential because they are sensitive to changes in membrane potential. When the membrane potential becomes more positive, these channels undergo a conformational change that allows them to open and allow sodium ions to flow into the cell. This influx of sodium ions depolarizes the membrane further, leading to the generation of an action potential. This process is crucial for the propagation of electrical signals along neurons and other excitable cells.

  • What is an acid residue ion, an oxonium ion, and a hydronium ion?

    An acid residue ion is a fragment of a molecule that remains after a hydrogen ion is removed from an acid. An oxonium ion is a positively charged ion formed by the addition of a proton to an oxygen atom. A hydronium ion is a positively charged ion formed by the combination of a water molecule with an extra proton, commonly found in aqueous solutions of acids.

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